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04.12.2019 To 04.12.2019

BEMC Talk, 04.12.2019: Causal Decision Analysis of Benefits, Harms and Cost-effectiveness – Estimands, Outcomes, Models and More

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Event for expert public only

Uwe Siebert, Hall in Tirol, Austria


Berlin is home to many epidemiologists, but there aren’t many local platforms for us to connect, learn new methods, and discuss current issues in the field. The Berlin Epidemiological Methods Colloquium (BEMC) seeks to fill this gap via interactive monthly BEMC Talks and BEMC JClub.

Decision analysis (or decision-analytic modeling) is a systematic approach to decision making under uncertainty that involves combining evidence for different estimands and outcomes from different study types and different sources in order to derive causal conclusions for future clinical, policy or research actions.
This talk provides an overview on the concepts and methods of causal decision-analytic modeling as a tool for (1) benefit-harm analysis informing clinical guidelines and personalized medical decision making, (2) cost-effectiveness analysis informing reimbursement decision making and (3) value-of-information analysis for future research prioritization.
Case examples of published decision analyses will be used to illustrate the fields of application, different model types, the importance of using causal model input parameters (particularly from real-world data), the choice of different estimands (e.g., from the ICH E9 framework) and their causal interpretations, approaches to integrate intercurrent events, as well as guidelines for best modeling practices, possible pitfalls in causal modeling, and future developments.

Organizational and administrative matters


Uwe Siebert, Hall in Tirol, Austria
Prof. Dr. Uwe Siebert, MPH, MSc, is Professor of Public Health, Medical Decision Making and Health Technology Assessment (UMIT), Adj. Professor of Health Policy and Management (Harvard Univ.) and the Cahir of the Department of Public Health, Health Services Research, and Health Technology Assessment.

Event organizer

Berlin Epidemiologic Methods Colloquium




Hertwig–Hörsaal (Oscar Hertwig-Haus, Anatomie), Charité Campus Mitte, 10117 Berlin
Look for our signs! If you are standing at the front of the Anatomy building in the park, the entrance is off to your left. It’s the same entrance as the CCM Medical Library, 1st floor.


Please register: BEMC Website



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